INSA LYON

Accumulating data suggest that bacterial genes are co-regulated along spatial genomic domains, even when they do not share any transcriptionfactor, thus escaping classical regulation models. The LoToReG project aims at explainingthese observations through a novel ancestral form of transcriptional regulation based onthe activity of RNA Polymerase (RNAPol) on DNA, through the formation of coupledtopological-transcriptional domains. The objective is to develop a quantitativecomputational modelling of this basal regulation mode. Our strategy integrates an analysisof novel high-throughput data obtained in the phytopathogenic Gram-negative bacteriumDickeya dadantii, together with a dynamic 1D modelling/simulation of the transcription –local topology coupled process along an entire chromosome.

 

https://anr.fr/Projet-ANR-18-CE45-0006

Visual: 
Laboratoires: 
Dates - Duration: 
10/2019 to 12/2022
Funding Institution: 
Contact: 
sam.meyer@insa-lyon.fr
Project Leader: 
INSA LYON - MAP
INSA’s scientific leader: 
Sam MEYER
Subtitle: 
Local Topology and global Regulation, modeling of a dynamicand multiscale coupling – LoToReg
Funding: 
185068' €'