CHROMATIN

LOTOREG

Keywords: 
CHROMATIN
TRANSCRIPTIONAL REGULATION
Local Topology and global Regulation, modeling of a dynamicand multiscale coupling – LoToReg
Project Leader: 
INSA LYON - MAP
INSA’s scientific leader: 
Sam MEYER

Accumulating data suggest that bacterial genes are co-regulated along spatial genomic domains, even when they do not share any transcriptionfactor, thus escaping classical regulation models. The LoToReG project aims at explainingthese observations through a novel ancestral form of transcriptional regulation based onthe activity of RNA Polymerase (RNAPol) on DNA, through the formation of coupledtopological-transcriptional domains. The objective is to develop a quantitativecomputational modelling of this basal regulation mode.

INSA Challenge: 
Santé Globale et Bioingénierie
Funding Institution: 
ANR
Dates - Duration: 
2019-10-01 00:00:00 to 2022-12-01 00:00:00
Funding: 
185068
Contact: 
sam.meyer@insa-lyon.fr