Architecture du chromosome et expression génique chez les bactéries
Project Leader:
INSA LYON-MAP
INSA’s scientific leader:
William NASSER
Bacterial adaptation to environmental changes requires a rapid reorganization of expression pattern of their genome. This adaptive response, which is critical for both bacterial survival and pathogenicity, is mediated by specific transcription factors, DNA supercoiling and global regulators represented by abundant nucleoid-associated-proteins (NAPs), which constrain supercoils and modulate both the chromatin structure and the transcription of numerous genes.
INSA Challenge:
Santé Globale et Bioingénierie
Partners:
INSTITUT PASTEUR-UNITE REGULATION SPATIALE DES GENOMES
Funding Institution:
ANR
Dates - Duration:
2023-10-01 00:00:00 to 2026-09-01 00:00:00
Funding:
513417
Contact:
william.nasser@insa-lyon.fr
Chapo:
Role of the spatial organization of the genome in the control of bacterial infection
Criblage métagénomique des déhalogénases, nouveaux outils pour la dépollution de la chlordécone
Project Leader:
INSA LYON
INSA’s scientific leader:
Philippe OGER
INSA Challenge:
Environnement : Milieux naturels, Industriels et Urbains
Partners:
INRAE
INSA LYON - ICBMS
ISYEB MNHN
Funding Institution:
ANR
Dates - Duration:
2022-12-01 00:00:00 to 2026-11-01 00:00:00
Funding:
349934
Contact:
philippe.oger@insa-lyon.fr
Chapo:
The MetHalo project aims at using a high-throughput functional screen based on flow-cytometry cell sorting to isolate and characterize novel families of dehalogenase proteins active against the persistant pollutant chlordecone
Déchiffrer les chemins et processus substitutionnels impliqués dans la thermoadaptation des protéomes procaryotes
Project Leader:
CNRS
INSA’s scientific leader:
Philippe OGER
In prokaryotes, the frequency of amino acids in proteomes is strongly correlated with the optimal growth temperature (OGT), but the associated substitutional patterns and their dynamics remain poorly understood. The ThermAdapt project addresses these two important issues through an original approach combining genomics, ancestral sequence reconstructions, structural modeling, experimental biology, and persistent homology. The ThermAdapt projects aims at:
INSA Challenge:
Environnement : Milieux naturels, Industriels et Urbains
Partners:
INSTITUT CAMILLE JORDAN
IBS
LBBE
Funding Institution:
ANR
Dates - Duration:
2023-01-01 00:00:00 to 2026-07-01 00:00:00
Funding:
498080
Contact:
philippe.oger@insa-lyon.fr
Chapo:
The ThermAdapt project aims to highlight the adaptive route taken by organisms to adapt to the temperature of their living environment, using an inference of phylogenetic relationships based on comparisons of three-dimensional protein structures in whole proteomes
Biocapteur optique combinant détection plasmonique et actuation diélectrophorétique
Project Leader:
ECOLE CENTRALE LYON
INSA’s scientific leader:
Guy CONDEMINE
A cause de l’augmentation de la population et de l’urbanisation, fournir une eau potable bactériologiquement sure devient un problème majeur. La raréfaction de l’eau va conduire à utiliser des eaux recyclées qui peuvent être porteuses de pathogènes. Il y a donc un besoin de développer des systèmes simples et rapides pour détecter ces bactéries dans l’eau. Les systèmes existant (mise en culture après centrifugation, PCR,etc…) sont longs et peu compatibles avec une détection sur site.
INSA Challenge:
Santé Globale et Bioingénierie
Partners:
CENTRALE LYON
CNRS
INSTITUT D'OPTIQUE
Funding Institution:
ANR
Dates - Duration:
2023-01-01 00:00:00 to 2027-01-01 00:00:00
Funding:
591695
Contact:
guy.condemine@insa-lyon.fr
Chapo:
Biocapteur optique basé sur la diélectrophorèse et la plasmonique pour une détection rapide et à faible seuil de détection de bactéries pathogènes dans l’eau
Submitted by Anonyme (not verified) on Mon, 04/25/2022 - 17:45
Artificial Cuticule : Assemblage biomimétique de polymères chitine-protéines: Interactions de surface pour la reconnaissance microbienne sur stylets d’hémiptères
Project Leader:
INSA LYON
INSA’s scientific leader:
Yves RAHBE
INSA Challenge:
Environnement : Milieux naturels, Industriels et Urbains
Submitted by Anonyme (not verified) on Fri, 12/11/2020 - 14:18
Project Leader:
INSA LYON
INSA’s scientific leader:
Guy CONDEMINE
Des bactéries d’espèces pathogènes pour les plantes peuvent être isolées dans des environnements variés tels que le sol, l’eau ou des plantes sauvages saines.
INSA Challenge:
Santé Globale et Bioingénierie
Partners:
INRAE CENTRE PACA
SORBONNE UNIVERSITE
UNIVERSITE DE LILLE
SWISS INSTITUTE OF BIOINFORMATICS/BIOINFORMATICS AND PROTEOGENOMICS
Submitted by Anonyme (not verified) on Wed, 10/07/2020 - 10:37
Keywords:
CHROMATIN
TRANSCRIPTIONAL REGULATION
Local Topology and global Regulation, modeling of a dynamicand multiscale coupling – LoToReg
Project Leader:
INSA LYON - MAP
INSA’s scientific leader:
Sam MEYER
Accumulating data suggest that bacterial genes are co-regulated along spatial genomic domains, even when they do not share any transcriptionfactor, thus escaping classical regulation models. The LoToReG project aims at explainingthese observations through a novel ancestral form of transcriptional regulation based onthe activity of RNA Polymerase (RNAPol) on DNA, through the formation of coupledtopological-transcriptional domains. The objective is to develop a quantitativecomputational modelling of this basal regulation mode.
Submitted by Anonyme (not verified) on Mon, 04/06/2020 - 15:02
Keywords:
INTERACTION PLANTE
Microorganism-plant communication: From microbial signals and their action to an integrated model of plant development
Project Leader:
ENS LYON - RDP
INSA’s scientific leader:
Sylvie REVERCHON
Comprendre et modéliser le fonctionnement intégré du complexe micro-organismes-plante pour le développement de nouvelles stratégies culturales basées sur l’ingénierie du microbiome.
Submitted by Anonyme (not verified) on Tue, 03/20/2018 - 08:00
Keywords:
EXTREME ENVIRONMENTS
MEMBRANE ADAPTATION
Des bicouches lipidiques stables au-delà du point d'ébullition de l'eau
Project Leader:
INSA LYON - MAP
INSA’s scientific leader:
Philippe OGER
Two major structural adaptations have been linked with the adaptation of the membrane to extreme pH and temperature environments: the synthesis of membrane-spanning, bipolar lipids and the binding of the glycerol moiety and the hydrocarbon chains by an ether bound. Bipolar lipids can form lipid monolayers, in which each polar headgroup points out on one side of the membrane. Monolayers are more rigid, less permeable and thermally more resistant than lipid bilayers.
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