Criblage métagénomique des déhalogénases, nouveaux outils pour la dépollution de la chlordécone
Project Leader:
INSA LYON
INSA’s scientific leader:
Philippe OGER
INSA Challenge:
Environnement : Milieux naturels, Industriels et Urbains
Partners:
INRAE
INSA LYON - ICBMS
ISYEB MNHN
Funding Institution:
ANR
Dates - Duration:
2022-12-01 00:00:00 to 2026-11-01 00:00:00
Funding:
349934
Contact:
philippe.oger@insa-lyon.fr
Chapo:
The MetHalo project aims at using a high-throughput functional screen based on flow-cytometry cell sorting to isolate and characterize novel families of dehalogenase proteins active against the persistant pollutant chlordecone
Rodent management is essential for health and economicissues. The only molecules approved by authorities and known to efficiently control rats andmice are 4-hydroxycoumarin (i.e., coumatetralyl, bromadiolone, difenacoum, brodifacoum,difethialone, flocoumafen) and 1,3-indandione (i.e., chlorophacinone) derivatives which areanticoagulant rodenticides (AR).
INSA Challenge:
Environnement : Milieux naturels, Industriels et Urbains
Submitted by Corinne Iafrate-Gran on Tue, 03/20/2018 - 08:00
Keywords:
EXTREME ENVIRONMENTS
MEMBRANE ADAPTATION
Des bicouches lipidiques stables au-delà du point d'ébullition de l'eau
Project Leader:
INSA LYON - MAP
INSA’s scientific leader:
Philippe OGER
Two major structural adaptations have been linked with the adaptation of the membrane to extreme pH and temperature environments: the synthesis of membrane-spanning, bipolar lipids and the binding of the glycerol moiety and the hydrocarbon chains by an ether bound. Bipolar lipids can form lipid monolayers, in which each polar headgroup points out on one side of the membrane. Monolayers are more rigid, less permeable and thermally more resistant than lipid bilayers.
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