Déchiffrer les chemins et processus substitutionnels impliqués dans la thermoadaptation des protéomes procaryotes
Project Leader:
CNRS
INSA’s scientific leader:
Philippe OGER
In prokaryotes, the frequency of amino acids in proteomes is strongly correlated with the optimal growth temperature (OGT), but the associated substitutional patterns and their dynamics remain poorly understood. The ThermAdapt project addresses these two important issues through an original approach combining genomics, ancestral sequence reconstructions, structural modeling, experimental biology, and persistent homology. The ThermAdapt projects aims at:
INSA Challenge:
Environnement : Milieux naturels, Industriels et Urbains
Partners:
INSTITUT CAMILLE JORDAN
IBS
LBBE
Funding Institution:
ANR
Dates - Duration:
2023-01-01 00:00:00 to 2026-07-01 00:00:00
Funding:
498080
Contact:
philippe.oger@insa-lyon.fr
Chapo:
The ThermAdapt project aims to highlight the adaptive route taken by organisms to adapt to the temperature of their living environment, using an inference of phylogenetic relationships based on comparisons of three-dimensional protein structures in whole proteomes
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