The goal of the project is to provide clinicians a fast and reliable, velocity quantification method to explore abnormal blood flow in the most anatomically

La maladie d'Alzheimer est la plus fréquente des démences dans la population sénescente. Elle toucherait
environ 10 millions de personnes dans le monde et ce nombre atteindrait 45 millions en 2050 selon l'OMS. Il s'agit
d'une maladie neurodégénérative caractérisée par une perte progressive de la mémoire et des facultés
cognitives, une désorientation spatiale et des changements de comportement. Le facteur de risque génétique
principal est l'allèle 4 du gène APOE (APOE4). Les caractéristiques pathologiques de cette maladie incluent la

L'objectif principal de ce projet d’amorçage est de renforcer un consortium existant afin de préparer la soumission d’un projet européen. Ce dernier vise à créer un jumeau virtuel pour améliorer les efforts de recherche clinique en cours et permettre une gestion personnalisée de l'arthropathie chez les patients atteints d'hémophilie sévère. Des ensembles de données complexes et détaillés seront collectés, incluant des données sérologiques, génétiques, d'IRM, d'échographie, de spectrométrie de masse, génomiques et environnementales des patients.

Bacterial adaptation to environmental changes requires a rapid reorganization of expression pattern of their genome. This adaptive response, which is critical for both bacterial survival and pathogenicity, is mediated by specific transcription factors, DNA supercoiling and global regulators represented by abundant nucleoid-associated-proteins (NAPs), which constrain supercoils and modulate both the chromatin structure and the transcription of numerous genes.

Non-ischemic chronic cardiomyopathies (NICM) represent a complex group of cardiac diseases, accounting for 40% of heart failure patients. The challenge in classification, diagnosis, and treatment stems from their multifactorial nature and clinical variability. Major subtypes include dilated and hypertrophic cardiomyopathies (DCM and HCM), each with distinct characteristics. These diseases can progress to heart failure and carry a risk of cardiac arrhythmias, including sudden death. Currently, there are no risk stratification scores for these patients.

As a biocompatible semiconductor composed of abundant elements, ZnO has received a huge interest for a wide variety of electronic, optoelectronic, chemical, and biological sensing applications. Thanks to its high PZ coefficients as a semiconductor, the integration of ZnO into PZ devices such as PZ nano-generators and/or pressure/strain sensors has extensively been considered in the last decade.

With 1.6 doctors per 1,000 people worldwide and 3.2 doctors per 1,000 people in France, medicine is under immense demographic pressure and providing appropriate access to care to the entire population is still a dream. According to the WHO, 1 in 4 people in Europe are affected by psychiatric disorders during their lifetime. In France, nearly 3 million people are affected by depression each year. An important challenge of artificial intelligence is to facilitate medical diagnoses.

Medical implants replace dysfunctional or missing body parts to maintain physiological functions. The associated market is growing by 4%/year. However, the key factor restraining the market is high implant costs. In this view, PEEK and CRF-PEEK due to biocompatibility, mechanical properties similar to that of bone and radiolucency, are increasingly used instead of metals. But, these biomaterials are bionert inducing a very limited osseointegration, which is THE expectation for bone implants.

Pulmonary embolism (the blockage of a pulmonary artery by a blood clot) is the third cause of cardiovascular death in Europe. Upon diagnosis confirmation, clinicians evaluate the patient prognosis based on risk stratification models. The management of patient, thus its outcome, highly depend on this risk stratification. Recent studies confirmed that patient stratification based on computed tomography pulmonary angiogram (CTPA) are not well correlated to patient prognosis.