Soutenance de thèse : Samaneh CHOUPANI

Intravascular manometry by clinical color Doppler

Doctorante : Samaneh CHOUPANI

Laboratoire INSA : CREATIS
Ecole doctorale : EDA162 MEGA

Assessment of the severity of arterial stenosis is critical for therapeutic decisions. Invasive methods using pressure wires to measure trans-stenotic pressure drops can have severe clinical side effects. Therefore, non-invasive methods using ultrasound imaging are preferable. This study aimed at introducing an ultrasound-based approach to estimate trans-stenotic pressure drops in significant arterial stenoses using clinical vascular color Doppler imaging. The proposed physics-constrained optimization method consists of two successive steps: 1) it recovers a regularized two-dimensional velocity vector field from the color Doppler velocity field, and 2) it derives relative pressures by integrating the fluid-dynamics Navier-Stokes equation using a finite difference method. We validated the innovative approach in silico using computational fluid dynamics and acoustics simulations and in vitro through particle image velocimetry and color Doppler experiments.