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Rodent management is essential for health and economicissues. The only molecules approved by authorities and known to efficiently control rats andmice are 4-hydroxycoumarin (i.e., coumatetralyl, bromadiolone, difenacoum, brodifacoum,difethialone, flocoumafen) and 1,3-indandione (i.e., chlorophacinone) derivatives which areanticoagulant rodenticides (AR).

The use of these molecules is associated with two grievousproblems: resistance phenomenon widespread in rodent populations and ecotoxicity due totheir bioaccumulation in rodent liver. The main aim of this project consists in the developmentof new rodent-specific inhibitors of VKORC1 able to overcome resistance in rodents. Thesenovel inhibitors should be highly specific to rodents, allowing the ecotoxicity problem leadingto wildlife mortality to be avoided or considerably diminished