INSTITUT PASTEUR-UNITE REGULATION SPATIALE DES GENOMES

CAGE

Tags: 
BIOAGRESSEUR
REGULATION DE L'EXPRESSION GENIQUE
Architecture du chromosome et expression génique chez les bactéries
Coordinateur: 
INSA LYON-MAP
Responsable INSA: 
William NASSER

Bacterial adaptation to environmental changes requires a rapid reorganization of expression pattern of their genome. This adaptive response, which is critical for both bacterial survival and pathogenicity, is mediated by specific transcription factors, DNA supercoiling and global regulators represented by abundant nucleoid-associated-proteins (NAPs), which constrain supercoils and modulate both the chromatin structure and the transcription of numerous genes.

Enjeu: 
Santé Globale et Bioingénierie
Partenaires: 
INSTITUT PASTEUR-UNITE REGULATION SPATIALE DES GENOMES
Financement: 
ANR
Dates projet: 
De 2023-10-01 00:00:00 hasta 2026-09-01 00:00:00
Montant global du projet: 
513417
Contact: 
william.nasser@insa-lyon.fr
Chapo: 
Role of the spatial organization of the genome in the control of bacterial infection